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BioNTech to Acquire Antibody Generation Unit of MAB Discovery

Mainz and Munich, Germany, January 23, 2019:

BioNTech AG, a rapidly growing biotechnology company developing precise and individualized immunotherapies for the treatment of cancer and the prevention of infectious diseases, and MAB Discovery GmbH, a unique player in the generation and development of sophisticated and therapeutically relevant monoclonal antibodies (mAbs), today announced that both partners have entered into a definitive agreement under which BioNTech will acquire MAB Discovery’s operational antibody generation unit.

Under the terms of the agreement, BioNTech will acquire all assets, employees and proprietary know-how for mAb generation from MAB Discovery. MAB Discovery will retain ownership of and all rights to both its proprietary preclinical development pipeline and its existing third-party service agreements. Financial terms of the agreement were not disclosed.

The acquisition follows a successful collaboration between the companies that started over five years ago, in which antibodies have been generated with MAB Discovery’s proprietary technology that are currently being further developed by BioNTech.

“Having exclusive access to MAB Discovery’s finely-tuned proprietary know-how dramatically expands BioNTech’s targeting ligand repertoire and enables us to directly, rapidly and efficiently produce new mAb candidates,” said Prof. Dr. Ugur Sahin, CEO and Co-Founder of BioNTech. “The technology will be utilized with our existing proprietary platforms including RiboMABS®, a platform for generating a novel class of mRNA-encoded antibody drug candidates.”

Administration of mRNA encoding an antibody using BioNTech’s RiboMABS® platform enables the human body to synthesize the corresponding protein antibody with therapeutic potential. This approach may profoundly reduce the complexity of future antibody drug development and increase the inventory of antibodies that could be used to treat disease. In 2017, BioNTech published the application of this technology for mRNA-based in vivo delivery of T cell-engaging bispecific antibodies for the potential treatment of cancer in Nature Medicine1.

“This transaction will ensure the further development and expansion of MAB Discovery’s unique mAb generation platform. We are glad to see that our proprietary technology has already generated unique mAbs for BioNTech and we are proud that MAB Discovery’s operational unit will become an integral part of BioNTech and its future value generation,” said Dr. Stephan Fischer, CEO of MAB Discovery. “MAB Discovery will now focus on further developing its proprietary mAbs with external partners.”

The acquisition will be completed and the antibody generation unit transitioned at the end of the first quarter of 2019.

About BioNTech

BioNTech is Europe’s largest privately-held biopharmaceutical company pioneering the development of more precise and individualized therapies for cancer and the prevention of infectious diseases. The company combines all building blocks for more precise and individualized immunotherapies under one roof – from diagnostics and drug development to manufacturing. Its cutting-edge technologies range from individualized mRNA-based product candidates through innovative chimeric antigen receptors and T-cell receptor-based compounds to novel checkpoint immunomodulators and small molecules. BioNTech’s commercial approach is validated by seven corporate partnerships with Genentech, a member of the Roche Group, Pfizer, Genmab, Eli Lilly and Company, Sanofi, Genevant and Bayer Animal Health and its scientific approach through over 60 peer-reviewed scientific publications, including five publications in Nature. Founded in 2008, BioNTech’s financial shareholders include the Struengmann Family Office as its majority shareholder, Fidelity Management & Research Company, Invus, Janus Henderson Investors, MIG Fonds, Redmile Group, Salvia and several European family offices. For more information, please see: www.biontech.de

 

About MAB Discovery

Founded in 2010 by Dr. Stephan Fischer, MAB Discovery utilizes a unique and proprietary rabbit-based antibody discovery platform to generate and develop high quality, functional monoclonal antibodies targeting traditional proteins and receptors as well as a wide variety of more challenging immunogens such as GPCRs and ion channels. The MAB Discovery team has extensive experience in developing antibody-based therapeutics having worked together at Roche Biologicals for several years. In recent years, MABD used its proprietary platform to generate various mAbs for several pharma partners and for the generation of proprietary mAbs focusing on highly attractive targets with proven therapeutic relevance.

For more information, please contact:

BioNTech
Sabine Steimle
Head Global Communications
Tel: +49 (0) 171 980 1089
Email: sabine.steimle@biontech.de

US Investor Enquiries
Westwicke Partners
John Woolford
Tel: +1 (443) 213 0506
Email: john.woolford@westwicke.com

MAB Discovery GmbH
Stephan Fischer, PhD
CEO, MAB Discovery
Tel + 49 (0) 89 990 1780
Email: stephan.fischer@mabdiscovery.com

Trophic Communications
Gretchen Schweitzer / Stephanie May
Tel: +49 (0)89 23 88 77 30
Email: may@trophic.eu


  1. Christiane R Stadler, Hayat Bähr-Mahmud,Leyla Celik,et al:
    Elimination of large tumors in mice by mRNA-encoded bispecific antibodies, in: Nature Medicine volume 23, pages 815–817 (2017)
    http://nature.com/articles/doi:10.1038/nm.4356

 

EUROSTARS grants Project Funding for SPARKLE Consortium - MAB Discovery technology will be employed for selection and development of therapeutic antibodies against drug-resistant Klebsiella pneumoniae

Neuried, Germany – April 5, 2018:

MAB Discovery GmbH is part of the SPARKLE consortium of five partners which receives 36 months funding from the EUSTARS program (https://www.eurostars-eureka.eu/project/id/11302). The unique MAB Discovery technology platform for the generation of novel monoclonal antibody drugs will be applied to pave the way for innovative treatments of severe infections by multidrug resistant bacteria.

The consortium will develop and perform the preclinical validation of an innovative therapeutic strategy against antibiotic-resistant Klebsiella pneumoniae (ARKP) infections. Klebsiella pneumoniae (KP) is a common hospital-acquired pathogen for which, due to resistance, treatment options are very limited. The therapy is based on a therapeutic monoclonal antibody (mAb) that specifically targets ARKP. Upon completion of the project, the mAb product will be ready for further clinical development.

“We are dedicated to deliver a set of novel molecules for the treatment and cure of severe infections. Being a part of the SPARKLE consortium broadens the scope of applications and underscores again the high performance of our rabbit-based antibody discovery platform,” said Dr. Stephan Fischer, CEO of MAB Discovery.

MAB Discovery delivers high quality, functional monoclonal antibodies via sophisticated, high-throughput selection of B cells generated by immunization and delivers a vast number of high quality candidates with regard to potency and epitope coverage. The use of wild type rabbits for immunization and the functional B-cell cloning strategy of MAB Discovery suits not only classical target proteins and receptors, but also to a wide variety of more challenging immunogens.

About MAB Discovery

Founded in 2010 by Dr. Stephan Fischer, MAB Discovery utilizes a unique rabbit-based antibody discovery platform to develop high quality, functional monoclonal antibodies targeting traditional proteins and receptors as well as a wide variety of more challenging immunogens such as GPCRs and ion channels. The MAB Discovery team has extensive experience in developing antibody-based therapeutics having worked together at Roche Biologicals for several years. The company follows a flexible collaboration-based business model to meet the needs of its clients and ongoing partners. For additional information, please visit www.mabdiscovery.com.

Contact:

MAB Discovery:
Stephan Fischer
+49 89 990 178-0
stephan.fischer@mabdiscovery.com

For media inquiries:
MC Services AG
Dr. Claudia Gutjahr-Löser
+49 89 210 228-0
contact@mc-services.eu

„DiscoEpiMapp“ – Neuen Antikörpern auf der Spur

Stuttgart / Tübingen, 4. April 2018

Erstes Forschungs- und Entwicklungsprojekt im biohymed-Kooperationsnetzwerk

(Stuttgart/Tübingen) – Das Zentrale Innovationsprogramm Mittelstand (ZIM) des Bundesministeriums für Wirtschaft und Energie (BMWi) fördert den Aufbau des Kooperationsnetzwerkes „biohymed“ zur Entwicklung biohybrider Produkte und Verfahren. Gemeinsam mit Universitäten, Kliniken und wissenschaftlichen Instituten aus der Region sowie kleinen bzw. mittelständischen Unternehmen forciert die BioRegio STERN Management GmbH damit gezielt die Biologisierung der Medizintechnik. Im März trafen sich die drei Partner des ersten Forschungsprojektes, die gemeinsam die Technologieplattform „DiscoEpiMapp“ zur Charakterisierung von Antikörpern für medizinische Zwecke entwickeln.

Das biohymed-Netzwerk bietet den beteiligten Partnern ideale Rahmenbedingungen, um Förderung durch das BMWi für innovative Forschungs- und Entwicklungsprojekte zu erhalten. Dazu gehört die Technologieplattform „DiscoEpiMapp“, die von drei Projektpartnern aus dem biohymed-Netzwerk, dem Naturwissenschaftlichen und Medizinischen Institut (NMI) an der Universität Tübingen aus Reutlingen, der INTAVIS Bioanalytical Instruments AG aus Tübingen und der MAB Discovery GmbH aus Neuried bei München, entwickelt wird. DiscoEpiMapp soll 3D-Strukturen von Epitopen, also Molekülabschnitte eines Antigens, gegen den das Immunsystem Antikörper bildet, untersuchen.

Die therapeutische Anwendung von Antikörpern und Antikörper-Medikamenten gewinnt zunehmend an Bedeutung. Ein erster wichtiger Schritt der Entwicklung therapeutischer Antikörper ist die Identifizierung von Zielmolekülen, den sogenannten Targets. Diese können anschließend auf ihre Relevanz für bestimmte Krankheitsbilder hin überprüft werden. Oft handelt es sich bei den Zielmolekülen um große Moleküle, die sich als „Rezeptoren“ auf Oberflächen von Zellen, wie beispielsweise Krebszellen, befinden. Sie übertragen Signale von außen, etwa zur Zellteilung, ins Innere der Zelle. Therapeutische Antikörper erkennen hierbei einen kleinen Teil des Zielmoleküls: das Epitop. Als Therapeutikum können sie die Funktion des Zielmoleküls blockieren, indem sie an dieses Epitop binden. Antikörper binden mit ihrer Binderegion meist ganz spezifisch „ihr“ Epitop, vergleichbar mit dem „Schlüssel-Schloss-Prinzip“. Die genaue Beschreibung des Epitops ist dabei von großer Bedeutung, um den Wirkmechanismus des potenziellen Therapeutikums zu verstehen. Die frühzeitige möglichst genaue Erkennung der Binderegion eines therapeutischen Antikörperkandidaten an sein Targetmolekül ist somit ein besonders kritischer Meilenstein in der Entwicklung neuer Antikörpermedikamente. Bisherige Methoden, wie die aufwändige Röntgenkristallographie, sind aufgrund ihres geringen Durchsatzes nur begrenzt einsetzbar.

Genau hier setzt DiscoEpiMapp an: Das Projektteam entwickelt einen neuartigen 3D-Peptid-Array als molekularbiologisches Untersuchungssystem, das eine umfangreiche, schnelle und zuverlässige dreidimensionale Charakterisierung unterschiedlicher Antikörperkandidaten für medizinische Zwecke ermöglicht. Hierbei erarbeitet INTAVIS als Spezialist auf dem Gebiet der membrangebundenen Peptid-Synthese die 3D-Peptid-Array-Technologie. MAB Discovery testet den 3D-Array und entwickelt begleitend ein neuartiges Hochleistungs-Produktionssystem für Antikörper. Das NMI erweitert das Verfahren durch eine HDX-Massenspektrometrie-Analytik zur Epitop-Charakterisierung.

Dr. Verena Grimm, Projektleiterin der BioRegio STERN Management GmbH, blickt auf die erfolgreiche Bewilligung der Förderung für dieses erste Forschungs- und Entwicklungsprojekt im Rahmen von biohymed zurück: „Das biohymed-Netzwerk soll den Projektpartnern die Möglichkeit geben, innovative Technologien für die Medizin der Zukunft zu entwickeln. Durch die Verknüpfung der Kompetenzen von INTAVIS und MAB Discovery in Kooperation mit dem NMI als etabliertem Netzwerkpartner unterstützen wir die Entwicklung einer neuen Technologie zum Screening, zur Produktion und zur Qualitätskontrolle therapeutischer monoklonaler Antikörper für die forschen den Unternehmen der Pharmabranche.“

Über die BioRegio STERN Management GmbH:

Die BioRegio STERN Management GmbH ist Wirtschaftsentwickler für die Life-Sciences-Branche. Sie fördert im öffentlichen Auftrag Innovationen und Start-ups und trägt so zur Stärkung des Standorts bei. In den Regionen Stuttgart und Neckar-Alb mit den Städten Tübingen und Reutlingen ist sie die zentrale Anlaufstelle für Gründer und Unternehmer. Die BioRegion STERN zählt zu den großen und erfolgreichen BioRegionen in Deutschland. Alleinstellungsmerkmale sind die bundesweit einzigartige Mischung aus Biotechnologie- und Medizintechnikunternehmen sowie die regionalen Cluster der Automatisierungstechnik, des Maschinen- und Anlagenbaus.

BioRegio STERN: seit Frühling 2015 Träger des Silver Labels des ESCA.
Pressekontakt:

BioRegio STERN Management GmbH
Dr. Klaus Eichenberg
Friedrichstraße 10
70174 Stuttgart
0711-870354-0
eichenberg@bioregio-stern.de

www.twitter.com/BioRegioSTERN
www.facebook.com/BioRegioSTERN

Redaktion

Zeeb Kommunikation GmbH
Anja Pätzold
Hohenheimer Straße 58a
70184 Stuttgart
0711-6070719
info@zeeb.info

 

Cullinan Oncology and MAB Discovery Announce Collaboration to Develop Novel Antibody-Based Therapeutics

CAMBRIDGE, Mass. USA, and NEURIED, Germany, February 20, 2018:

CullinanOncology, LLC and MAB Discovery GmbH (MABD), announced today the initiation of a
collaboration to develop novel antibody therapeutics based on MABD’s unique discovery platform.

“We are excited to enter into this collaboration as the MABD development engine provides us with access to highly differentiated monoclonal antibodies” said Patrick Baeuerle, Cullinan’s Chief Scientific Officer, Biologics. “Our first program is a novel agonistic antibody that has the potential to be a pillar of future immuno-oncology and standard treatments. We look forward to working with Stephan Fischer and the MABD team to execute the development plan and progress the asset into the clinic.”

Under the terms of the agreement, MABD has the potential to receive cash payments upon the achievement of various milestones in addition to an upfront equity interest in Cullinan Wittelsbach, a subsidiary of Cullinan Oncology LLC formed to fund and shepherd the development of the asset.

Dr. Stephan Fischer, CEO of MAB Discovery, stated, “We are delighted to partner with Patrick and the Cullinan team, and look forward to understanding how the unique attributes of our rabbit-based platform translate into highly differentiated antibodies that have the potential to significantly advance patient outcomes.”

 

About Cullinan Oncology

Cullinan Oncology is focused on investing in and developing a highly diversified portfolio of oncology therapeutics with a unique, cost-efficient business model. Sourced from the Cullinan dry lab as well as external collaborators, the company’s assets are managed by a single, highly experienced team of oncology professionals and drug developers across a lean, capital efficient operating model. Cullinan is backed by the UBS Oncology Impact Fund (OIF) managed by MPM Capital, a worldwide leader in oncology investing, and F2 Ventures. For additional information, please visit www.cullinanoncology.com.

About MAB Discovery

Founded in 2010 by Dr. Stephan Fischer, MAB Discovery utilizes a unique rabbit-based antibody discovery platform to develop high quality, functional monoclonal antibodies targeting traditional proteins and receptors as well as a wide variety of more challenging immunogens such as GPCRs and ion channels. The MAB Discovery team has extensive experience in developing antibody-based therapeutics having worked together at Roche Biologicals for several years. The company follows a flexible collaboration-based business model to meet the needs of its clients and ongoing partners. For additional information, please visit www.mabdiscovery.com.

 

Collaboration project agreement between MAB Discovery GmbH and BioNTech AG

Neuried, Germany - November 6, 2017:
MAB Discovery GmbH today announced that it has entered into the second collaboration project agreement with BioNTech AG, Mainz. The unique MAB Discovery technology platform for the generation of novel antibody therapeutics will be applied for proprietary targets provided by BioNTech. Financial terms of the agreement were not disclosed.

“We are excited to be selected again as a partner for BioNTech. This underscores the high performance of our rabbit-based antibody discovery platform,” said Dr. Stephan Fischer, CEO of MAB Discovery.

Sean Marett, COO of BioNTech added, “Our collaboration with MAB Discovery in 2013 was highly productive and we are delighted to expand our relationship to generate unique antibodies against a set of therapeutically relevant targets.”

MAB Discovery delivers high quality, functional monoclonal antibodies via sophisticated, high-throughput selection of B cells generated by immunization, and delivers a vast number of high quality candidates with regard to potency and epitope coverage. The use of wild type rabbits for immunization and the functional B-cell cloning strategy of MAB Discovery suits not only classical target proteins and receptors, but also to a wide variety of more challenging immunogens, e.g. GPCRs, ion channels, carbohydrates, and small sized epitopes.

About MAB Discovery GmbH

MAB Discovery, based in Munich, was founded and established in 2010 by experienced pharma scientists with proven track record in drug development. MAB Discovery complies with the highest industrial standards of big pharma, but operates with the flexibility, speed and innovative spirit of young biotech’s. The company’s outstanding technology platform generally offers its collaboration partners access to a large variety of functional drug candidates to choose from, and a unique route to CMC-compliant humanized mAb’s in 10-12 months.

Contact:

MAB Discovery:
Stefan Müllner
+49 89 990 178-0
stefan.muellner@mabdiscovery.com

For media inquiries:
MC Services AG
Dr. Claudia Gutjahr-Löser
+49 89 210 228-0
contact@mc-services.eu

 

BioEurope


MAB Discovery will attend this years BioEurope in Berlin, November 6-8. We will be excited to meeting with you there to discuss your individual development projects.